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Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma
- Ricketts, Christopher J., Linehan, W. Marston
- Cell 2018 v.173 no.3 pp. 540-542
- metastasis, patients, renal cell carcinoma
- Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.