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A Mechanosensitive GPCR that Detects the Bloody Force
- Iliff, Adam J., Xu, X.Z. Shawn
- Cell 2018 v.173 no.3 pp. 542-544
- G-protein coupled receptors, blood flow, blood vessels, endothelial cells, hearing, ion channels, mechanoreceptors, proprioception
- Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.