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Evaluation of magnetic nanoparticles influence on hyaluronic acid production from Streptococcus equi
- Attia, Yasser A., Kobeasy, Mohamed I., Samer, Mohamed
- Carbohydrate polymers 2018 v.192 pp. 135-142
- Streptococcus equi, additives, glutamic acid, hyaluronic acid, iron oxides, magnetism, nanoparticles, stabilizers
- This work aims at developing a novel hyaluronic acid (HA) production method using magnetic nanoparticles (NPs). In a separate process, HA was produced with the addition of the amino acids (AA) as bio-additives. Regarding the NPs additives, the results showed that the highest dry weight of the produced HA was 0.264 g/l with the addition of 20 mg/l of Fe3O4 NPs. Concerning the AA additives, the results showed that the highest dry weight of the produced HA was 0.079 g/l with the addition of 0.26 g/l of glutamic acid (GA) compared to the control produced 0.065 g/l. These results led to further develop a novel HA production method which is preparing the Fe3O4 NPs using GA as stabilizer, where the results showed that dry weight of the produced HA was 0.435 g/l with the addition of 20 mg/l of Fe3O4-GA NPs.