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Antidiabetic activity of mefloquine via GLP-1 receptor modulation against STZ–NA-induced diabetes in albino wistar rats

Yadav, RajnishKumar, Rawat, JitendraK., Gautam, Swetlana, Singh, Manjari, Kumar, Manish, Ansari, MohdNazam, Roy, Subhadeep, Saeedan, AbdulazizS., Kaithwas, Gaurav
3 Biotech 2018 v.8 no.5 pp. 240
agonists, animal disease models, antioxidants, blood glucose, blood serum, catalase, electrocardiography, glucagon, glucagon-like peptide 1, glycemic control, glycemic effect, glycogen, heart rate, hepatotoxicity, insulin, intraperitoneal injection, laboratory animals, liver, metformin, nicotinamide, nitric oxide, noninsulin-dependent diabetes mellitus, oral administration, rats, streptozotocin, superoxide dismutase
Mefloquine was retrieved as a glucagon -like peptide-1 receptor agonist and, therefore, evaluated for its antidiabetic potential against non-insulin-dependent diabetes mellitus (NIDDM) in experimental animals. NIDDM was induced by single intraperitoneal injection of streptozotocin and nicotinamide (60 + 110 mg/kg) in albino wistar rats. The experimental animals were scrutinised for electrocardiographic (ECG) and heart rate variability (HRV) factors to study the autonomic dysfunction along with blood glucose, serum insulin, and liver glycogen levels for glycemic control. Simultaneously, antioxidant markers (TBARs, protein carbonyl, GSH, SOD, catalase) and inflammatory markers (COX, LOX, NO) were scrutinized as well. Oral administration of mefloquine normalised the heart rate with favourable regulation of time and frequency domain HRV parameters. Mefloquine restored the blood glucose, serum insulin, and liver glycogen levels favourably in diabetic rats. Treatment with mefloquine curtailed the antioxidant markers with favourable regulation of inflammatory signals. Mefloquine was also found to be less hepatotoxic in contrast to the standard metformin, providing an integrated advantage as an antidiabetic agent.