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Genome engineering for CNS injury and disease
- Pardieck, Jennifer, Sakiyama-Elbert, Shelly
- Current opinion in biotechnology 2018 v.52 pp. 89-94
- central nervous system, gene editing, methodology, models
- Recent developments in genome engineering methods have advanced our knowledge of central nervous system (CNS) function in both normal health and following disease or injury. This review discusses current literature using gene editing tools in CNS disease and injury research, such as improving viral-mediated targeting of cell populations, generating new methods for genome editing, reprogramming cells into CNS cell types, and using organoids as models of development and disease. Readers may gain inspiration for continuing research into new genome engineering methods and for therapies for CNS applications.