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Bionanotechnology for vaccine design
- Frey, Steven, Castro, Ana, Arsiwala, Ammar, Kane, Ravi S
- Current opinion in biotechnology 2018 v.52 pp. 80-88
- antigens, bacteria, immune response, immune system, ligands, pathogens, vaccines, viruses
- There have been significant advances in the design of nanostructured scaffolds for eliciting robust immune responses. One method to produce strong immune responses is to emulate the appearance of a pathogen. Since pathogens such as viruses and bacteria often display multiple copies of ligands on their surfaces, the immune system is particularly sensitive towards multivalent displays of antigens. Consequently, when designing a vaccine, it is advantageous to decorate a nanostructured surface with multiple copies of an antigen. This review highlights the design and efficacy of a diverse set of recently developed nanostructured vaccine scaffolds.