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Genetic Vulnerability of GPCRs: A Call to Action
- Liggett, Stephen B.
- Trends in biochemical sciences 2018 v.43 pp. 227-229
- G-protein coupled receptors, drugs, genetic variation, humans
- G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The ‘one-drug-fits-all’ approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices.