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Genetic Vulnerability of GPCRs: A Call to Action

Author:
Liggett, Stephen B.
Source:
Trends in biochemical sciences 2018 v.43 pp. 227-229
ISSN:
0968-0004
Subject:
G-protein coupled receptors, drugs, genetic variation, humans
Abstract:
G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The ‘one-drug-fits-all’ approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices.
Agid:
5937541