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Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease

Author:
Leo, Fabian, Zeh, Michael, Prothmann, Annegret, Kurzai, Oliver, Kurz, Sylke, Grohé, Christian
Source:
Medical mycology case reports 2018 v.20 pp. 28-32
ISSN:
2211-7539
Subject:
adults, amphotericin B, case studies, drug therapy, fever, histopathology, immunosuppression, larynx, mycology, patients, pneumonia, surgery
Abstract:
We report a case of tracheal, laryngeal and pulmonary mucormycosis in a patient receiving immunosuppressive medication for an autoinflammatory fever syndrome. Mucormycosis was confirmed by histopathology from tracheal specimens and molecular evidence of Lichtheimia.A surgical approach was not possible because of the multifocal disease pattern and the extent of tracheal involvement. The patient was successfully treated with liposomal amphotericin B followed by posaconazole maintenance therapy. After 9 months, recurrent pulmonary mucormycosis was suspected but emerged as organizing pneumonia without evidence of active fungal infection.
Agid:
5938304