PubAg

Main content area

DNA Repair: The Search for Homology

Author:
Haber, James E.
Source:
BioEssays 2018 v.40 no.5 pp. e1700229
ISSN:
0265-9247
Subject:
DNA repair, genome, homologous recombination
Abstract:
The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51‐mediated process to match sequences at the broken end to homologous donor sequences that can be used as a template to repair the lesion. Here, in reviewing research about DSB repair, I consider the many factors that appear to play important roles in the successful search for homology by several homologous recombination mechanisms. See also the video abstract here: https://youtu.be/vm7-X5uIzS8.
Agid:
5939056