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A living model for obesity and aging research: Caenorhabditis elegans
- Shen, Peiyi, Yue, Yiren, Park, Yeonhwa
- Critical reviews in food science and nutrition 2018 v.58 no.5 pp. 741-754
- Alzheimer disease, Caenorhabditis elegans, animal models, body size, free-living nematodes, genes, human diseases, longevity, neurodegenerative diseases, obesity
- Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively utilized as an animal model for research involving aging and neurodegenerative diseases, like Alzheimer's and Parkinson's, etc. Compared with traditional animal models, this small nematode possesses many benefits, such as small body size, short lifespan, completely sequenced genome, and more than 65% of the genes associated with human disease. All these characteristics make this organism an ideal living system for obesity and aging studies. This review gives a brief introduction of C. elegans as an animal model, highlights some advantages of research using this model and describes methods to evaluate the effect of treatments on obesity and aging of this organism.