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Acute effects of PM2.5 on lung function parameters in schoolchildren in Nanjing, China: a panel study

Xu, Dandan, Zhang, Yi, Zhou, Lian, Li, Tiantian
Environmental science and pollution research international 2018 v.25 no.15 pp. 14989-14995
acute effects, acute exposure, air pollution, developing countries, experimental design, health promotion, lung function, particulates, regression analysis, school children, China
The association between exposure to ambient particulate matter (PM) and reduced lung function parameters has been reported in many works. However, few studies have been conducted in developing countries with high levels of air pollution like China, and little attention has been paid to the acute effects of short-term exposure to air pollution on lung function. The study design consisted of a panel comprising 86 children from the same school in Nanjing, China. Four measurements of lung function were performed. A mixed-effects regression model with study participant as a random effect was used to investigate the relationship between PM₂.₅ and lung function. An increase in the current day, 1-day and 2-day moving average PM₂.₅ concentration was associated with decreases in lung function indicators. The greatest effect of PM₂.₅ on lung function was detected at 1-day moving average PM₂.₅ exposure. An increase of 10 μg/m³ in the 1-day moving average PM₂.₅ concentration was associated with a 23.22 mL decrease (95% CI: 13.19, 33.25) in Forced Vital Capacity (FVC), a 18.93 mL decrease (95% CI: 9.34, 28.52) in 1-s Forced Expiratory Volume (FEV₁), a 29.38 mL/s decrease (95% CI: -0.40, 59.15) in Peak Expiratory Flow (PEF), and a 27.21 mL/s decrease (95% CI: 8.38, 46.04) in forced expiratory flow 25–75% (FEF₂₅–₇₅%). The effects of PM₂.₅ on lung function had significant lag effects. After an air pollution event, the health effects last for several days and we still need to pay attention to health protection.