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Conjugated Polymer Containing Organic Radical for Optical/MR Dual-Modality Bioimaging
- Hou, Meirong, Lu, Xiaodan, Zhang, Zhide, Xia, Qi, Yan, Chenggong, Yu, Zhiqiang, Xu, Yikai, Liu, Ruiyuan
- ACS applied materials & interfaces 2017 v.9 no.51 pp. 44316-44323
- biocompatibility, cytotoxicity, fluorescence, image analysis, magnetic resonance imaging, polymers, tissues
- Optical/MRI bimodal probes have attracted much attention due to palmary soft tissue resolution and high imaging sensitivity. In this study, poly[fluorene-co-alt-p-phenylene] containing organic radical (PFP-TEMPO+) is successfully developed for optical and MRI dual-modality bioimaging. PFP-TEMPO+ displays advanced properties such as fluorescence emission, high photostablilty, reasonable T₁ relaxation effect, low cytotoxicity, and good biocompatibility. Moreover, the ability of PFP-TEMPO+ for tumor tissues imaging confirms that it could be used as an optical and MRI imaging probe for in vivo imaging. The results of the present work disclose the potential applications of PFP-TEMPO+ as an optical and MRI contrast agent.