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Anti-neuroinflammatory diterpenoids from the endangered conifer Podocarpus imbricatus
- Hu, Chang-Ling, Xiong, Juan, Xiao, Chen-Xi, Tang, Yu, Ma, Guang-Lei, Wan, Jiang, Hu, Jin-Feng
- Journal of Asian natural products research 2018 v.20 no.2 pp. 101-108
- Dacrycarpus imbricatus, branches, conifers, diterpenoids, gardens, inhibitory concentration 50, lipopolysaccharides, mice, neuroglia, nitric oxide, spectroscopy
- Ten diterpenoids including three new abietanes (1–3) were isolated from the twigs and needles of Podocarpus imbricatus, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3β-hydroxy-abieta-8,11,13-trien-7-one (5), decandrin G (6), and 7,15-pimaradien-18-oic acid (8) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC₅₀ values of 3.7, 11.1, and 4.5 μM, respectively.