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A new triterpene ester and other chemical constituents from the aerial parts of Anodendron paniculatum and their cytotoxic activity

Author:
Viet Ho, Duc, Thi Hoang, Hanh Nhu, Quoc Vo, Hung, Minh Nguyen, Hien, Raal, Ain, Thi Nguyen, Hoai
Source:
Journal of Asian natural products research 2018 v.20 no.2 pp. 188-194
ISSN:
1477-2213
Subject:
Anodendron, aerial parts, chemical composition, cytotoxicity, human cell lines, humans, inhibitory concentration 50, neoplasm cells, phthalates, stigmasterol, ursolic acid
Abstract:
The aim of the research was to study the active constituents of Anodendron paniculatum Roxb. (Apocynaceae). A new triterpene ester, named anopaniester (1), and cycloartenol (2), ursolic acid (3), esculenic acid (4), bis-(2-ethylhexyl) phthalate (5), desmosterol (6), stigmasterol (7), vaniline (8), and (E)-phytol (9), were isolated from the aerial parts of A. paniculatum. Compounds 3 and 6 showed the significant inhibitory effect (IC₅₀ values ranging from 30.89 ± 3.60 to 44.37 ± 5.40 μg/ml) against tested human cancer cell lines LU-1 and MKN-7. The compounds 1–4, and 6 were isolated from this genus Anodendron for the first time.
Agid:
5952626