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Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives

Author:
Qin, Yin-Lin, Chen, Lei, He, Wei, Su, Mei, Jin, Qiu, Fang, Zheng, Ouyang, Ping-Kai, Guo, Kai
Source:
Journal of Asian natural products research 2018 v.20 no.2 pp. 139-147
ISSN:
1477-2213
Subject:
cardioprotective effect, chemical derivatives, chlorination, quinones, synthesis
Abstract:
A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.
Agid:
5952628