Main content area

The Effect of Vitamin D Supplementation on Breast Density Changes: A Clinical Trial Study

Alipour, Sadaf, Shirzad, Nooshin, Sepidarkish, Mahdi, Saberi, Azin, Bayani, Leila, Hosseini, Ladan
Nutrition and cancer 2018 v.70 no.3 pp. 425-430
breasts, cholecalciferol, clinical trials, regression analysis, vitamin E, women
The aim of this study was to determine the effect of supplementation with 50,000 IU/monthly vitamin D for 1 yr on breast density in Iranian women. Methods: This double-blind, placebo-controlled, single center clinical trial was conducted among 400 women aged 40 yr and older. Participants were allocated to 2 groups. Group 1 received vitamin D (Cholecalciferol) 50,000 IU in tablet form, monthly, for 1 yr. Group 2 received vitamin E 400 IU in tablet form, monthly, for the same period of time. Participants had follow-up clinic visits every 6 mo and received an annual mammogram. Results: Final data were evaluated based on 216 and 194 women in the vitamin D and control groups. The mean decrease in mammographic density was −5.01%(95% CI, −9.9% to −0.01%) and −2.34 %(95% CI, −6.84% to −2.15%) in the vitamin D and control groups, respectively. There was no significant association between vitamin D consumption and breast density after 1 yr (OR = 0.7, 95% CI, 0.46 to 1.06; P = 0.1).Similar results were observed when multivariate model of logistic regression analysis was performed. Conclusions: This study showed that monthly consumption of 50,000 IU of vitamin D supplementation for 1 yr did not affect breast density.