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Antitumor Properties of CLA-Enriched Food Products

Author:
Koronowicz, Aneta A., Banks, Paula
Source:
Nutrition and cancer 2018 v.70 no.4 pp. 529-545
ISSN:
1532-7914
Subject:
agonists, antineoplastic activity, apoptosis, conjugated linoleic acid, dairy products, eggs, gene expression, ligands, meat, mitochondria, neoplasm cells, neoplasms, peroxisome proliferator-activated receptors, signal transduction
Abstract:
In this manuscript, we reviewed the available literature on the effects of conjugated linoleic acid (CLA)-enriched food products, including meat, dairy products, and eggs on cancer, both in vivo and in vitro. Based on our own studies on CLA-enriched eggs, we also identified potential molecular mechanisms by which such products may act on cancer cells. We propose the mitochondrial apoptosis pathway as mainly accountable for the reduction of cancer cells viability. Our hypothesis is supported by observed changes in expression of genes associated with downregulation of AKT/mTOR signalling pathway. In addition, we propose that CLA-enriched food products can act as peroxisome proliferator-activated receptors (PPAR) ligands showing predominately an agonist effect on PPAR isoforms.
Agid:
5953106