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Two new 2-(2-Hydroxy-2-phenylethyl)chromens from agarwood originating from Aquilaria crassna

Author:
Wang, Hong-Ni, Mei, Wen-Li, Dong, Wen-Hua, Kong, Fan-Dong, Li, Wei, Yuan, Jing-Zhe, Dai, Hao-Fu
Source:
Journal of Asian natural products research 2018 v.20 no.2 pp. 122-127
ISSN:
1477-2213
Subject:
Aquilaria crassna, Ralstonia solanacearum, acetylcholinesterase, antibacterial properties, nuclear magnetic resonance spectroscopy
Abstract:
Two new 2-(2-hydroxy-2-phenylethyl)chromones (1‒2), along with three known 2-(2-phenylethyl)chromones (3‒5), were isolated from the agarwood originating from Aquilaria crassna Pierre ex Lecomte. Their structures were determined by the spectroscopic methods including 1D and 2D NMR analysis and comparison with reported data in the literature. All the compounds were isolated from agarwood of A. crassna for the first time. Compounds 1 and 2 exhibited inhibitory activity against acetylcholinesterase (AChE) with 17.4 ± 0.6 and 15.8 ± 0.7%, respectively, at a concentration of 50 μg/ml. Besides, Compound 3 expressed antibacterial activities against Ralstonia solanacearum with diameter of the inhibition zone of 6.80 ± 0.08 mm at a concentration of 10 mg/ml.
Agid:
5953412