PubAg

Main content area

Four new monacolin analogs from Monascus purpureus-fermented rice

Author:
Zhang, Bo, Liu, Tian-Xi, Wang, A-Li, Li, Jin-Jie, Wang, Xin, Luan, Na, Ji, Lin-Lin, Shang, Xiao-Ya
Source:
Journal of Asian natural products research 2018 v.20 no.3 pp. 209-216
ISSN:
1477-2213
Subject:
Monascus, cytotoxicity, mass spectrometry, nuclear magnetic resonance spectroscopy, rice
Abstract:
Four new monacolin analogs, monacolin T (1), monacolin U (2) 6a-O-methyl-4,6-dihydromonacolin L (3), and 6a-O-ethyl-4,6-dihydromonacolin L (4) were isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures were determined by a combination of 1D, 2D NMR experiments (¹H-¹HCOSY, HSQC, HMBC, and ROESY), and mass spectrometry. In vitro cytotoxic assay, all compounds were inactive at the concentration of 10 µM.
Agid:
5953420