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Four new monacolin analogs from Monascus purpureus-fermented rice
- Zhang, Bo, Liu, Tian-Xi, Wang, A-Li, Li, Jin-Jie, Wang, Xin, Luan, Na, Ji, Lin-Lin, Shang, Xiao-Ya
- Journal of Asian natural products research 2018 v.20 no.3 pp. 209-216
- Monascus, cytotoxicity, mass spectrometry, nuclear magnetic resonance spectroscopy, rice
- Four new monacolin analogs, monacolin T (1), monacolin U (2) 6a-O-methyl-4,6-dihydromonacolin L (3), and 6a-O-ethyl-4,6-dihydromonacolin L (4) were isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures were determined by a combination of 1D, 2D NMR experiments (¹H-¹HCOSY, HSQC, HMBC, and ROESY), and mass spectrometry. In vitro cytotoxic assay, all compounds were inactive at the concentration of 10 µM.