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Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp

Author:
El-Demerdash, Amr, Moriou, Céline, Martin, Marie-Thérèse, Petek, Sylvain, Debitus, Cécile, Al-Mourabit, Ali
Source:
Natural product research 2018 v.32 no.13 pp. 1512-1517
ISSN:
1478-6427
Subject:
alkaloids, cytotoxicity, humans, inhibitory concentration 50, neoplasm cells, neoplasms, spectral analysis
Abstract:
Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2–3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC₅₀ values in the micromolar range.
Agid:
5954030