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Xylaropyrones B and C, new γ-pyrones from the endophytic fungus Xylaria sp. SC1440

Author:
Guo, Chenjia, Wu, Ping, Xue, Jinghua, Li, Hanxiang, Wei, Xiaoyi
Source:
Natural product research 2018 v.32 no.13 pp. 1525-1531
ISSN:
1478-6427
Subject:
Xylaria, cytotoxicity, endophytes, enzyme inhibition, fungi, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Two new γ-pyrones, xylaropyrones B (1) and C (2), together with three known compounds, xylaropyrone (3), annularin A (4) and annularin C (5), were isolated from solid cultures of the endophytic fungus Xylaria sp. SC1440. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative configurations of 1 and 2 were assigned on the basis of J-based configurational analysis, and the absolute configurations were established by experimental and TDDFT calculated ECD spectra. The isolated compounds were evaluated for cytotoxic and tyrosinase inhibitory activity.
Agid:
5954032