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A new lactam alkaloid from Portulaca oleracea L. and its cytotoxity

Author:
Zhao, Chengcheng, Ying, Zheming, Tao, Xiaojun, Jiang, Mingyue, Ying, Xixiang, Yang, Guanlin
Source:
Natural product research 2018 v.32 no.13 pp. 1548-1553
ISSN:
1478-6427
Subject:
Portulaca oleracea, alkaloids, cytotoxicity, lactams, medicine, nuclear magnetic resonance spectroscopy
Abstract:
A new lactam alkaloid named oleraciamide D (1), indentified as (5R)-4-(3-methoxy-4-hydroxyphenyl)-5-(4-hydroxyphenyl)-5,6-dihydropyridin-2(1H)-one, together with five known compounds, indole-3-aldehyde (2), portulacatone (3), N-trans-feruloyloctopamine (4), N-trans-feruloyl-3′-O-methyldopamine (5) and N-trans-feruloyltyramine (6) were isolated from Potulaca oleracea L. Among them, indole-3-aldehyde (2) was isolated from the medicine for the first time. The structure of the new alkaloid was elucidated via UHPLC-ESI-Q-TOF/MS, 1D NMR and 2D NMR. The five known compounds were established by comparing the ¹H-NMR and ¹³C NMR with the reported literature. Oleraciamide D (1) showed cytotoxicity against SH-SY5Y cells when concentration at 50 uM by CCK-8 method.
Agid:
5954036