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Design and Synthesis of a Biocompatible 1D Coordination Polymer as Anti-Breast Cancer Drug Carrier, 5-Fu: In Vitro and in Vivo Studies
- Rezaei, Mahsa, Abbasi, Alireza, Dinarvand, Rassoul, Jeddi-Tehrani, Mahmood, Janczak, Jan
- ACS applied materials & interfaces 2018 v.10 no.21 pp. 17594-17604
- animal models, breast neoplasms, carboxylic acids, cell lines, confocal laser scanning microscopy, coordination polymers, cytotoxicity, drug carriers, drug therapy, encapsulation, fluorescein, fluorouracil, hydrogen bonding, isothiocyanates, microparticles, neoplasm cells, staining, zinc
- Designable coordination polymers with suitable chemical diversities and biocompatible structures have been proposed as a promising class of vehicles for drug delivery systems. Here, we hydrothermally synthesized a novel one-dimensional (1D) coordination polymer, [Zn(H₂O)₆K₂(H₂BTC)₂(H₂O)₄](H₂BTC)₂·2H₂O, where H₃BTC = benzene-1,3,5-tricarboxylic acid (trimesic acid), cp.1. As the hydrogen bonds stabilized 1D chains in three dimensions, the cp.1 could be a good candidate for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu). The synthesized cp.1 showed a remarkable 5-Fu loading of 66% with encapsulation efficiency of 98% and almost complete release process. The 5-Fu-loaded cp.1 displayed a time-dependent cytotoxicity effect against breast cancer cell lines MCF-7 and 4T1. The cellular uptake of cp.1 particles was investigated via confocal laser scanning microscopy using fluorescein isothiocyanate and LysoTracker Red staining. Furthermore, the in vivo antitumor impact of 5-Fu-loaded cp.1 was studied on 4T1 breast cancer BALB/c mice model. The intratumor treatment of 5-Fu-loaded cp.1 demonstrated beneficial antitumor efficacy by postponing tumor growth. These results suggest that the 5-Fu-loaded cp.1 microparticles with a great locoregional delivery can be efficient anticancer drug carriers for further clinical treatments.