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Prion propagation and inositol polyphosphates

Author:
Wickner, ReedB., Edskes, HermanK., Bezsonov, EvgenyE., Son, Moonil, Ducatez, Mathieu
Source:
Current genetics 2018 v.64 no.3 pp. 571-574
ISSN:
0172-8083
Subject:
RNA transport, amyloid, energy, inositols, messenger RNA, metabolism, polymers, polyphosphates, prions, telomeres
Abstract:
The [PSI+] prion is a folded in-register parallel β-sheet amyloid (filamentous polymer) of Sup35p, a subunit of the translation termination factor. Our searches for anti-prion systems led to our finding that certain soluble inositol polyphosphates (IPs) are important for the propagation of the [PSI+] prion. The IPs affect a wide range of processes, including mRNA export, telomere length, phosphate and polyphosphate metabolism, energy regulation, transcription and translation. We found that 5-diphosphoinositol tetra(or penta)kisphosphate or inositol hexakisphosphate could support [PSI+] prion propagation, and 1-diphosphoinositol pentakisphosphate appears to inhibit the process.
Agid:
5964477