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Fixation of carbon dioxide by a hydrogen-oxidizing bacterium for value-added products

Yu, Jian
World journal of microbiology & biotechnology 2018 v.34 no.7 pp. 89
Cupriavidus necator, bioreactors, carbon dioxide, carbon dioxide fixation, electrolysis, feedstocks, fermentation, gases, hydrogen, hydrogen-oxidizing bacteria, metabolic engineering, metabolites, nutrients, polyhydroxyalkanoates, prokaryotic cells, value-added products
With rapid technology progress and cost reduction, clean hydrogen from water electrolysis driven by renewable powers becomes a potential feedstock for CO₂ fixation by hydrogen-oxidizing bacteria. Cupriavidus necator (formally Ralstonia eutropha), a representative member of the lithoautotrophic prokaryotes, is a promising producer of polyhydroxyalkanoates and single cell proteins. This paper reviews the fundamental properties of the hydrogen-oxidizing bacterium, the metabolic activities under limitation of individual gases and nutrients, and the value-added products from CO₂, including the products with large potential markets. Gas fermentation and bioreactor safety are discussed for achieving high cell density and high productivity of desired products under chemolithotrophic conditions. The review also updates the recent research activities in metabolic engineering of C. necator to produce novel metabolites from CO₂.