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Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats

Author:
Ahmad, Uswa, Ahmad, Rabia Shabir
Source:
BMC complementary and alternative medicine 2018 v.18 no.1 pp. 179
ISSN:
1472-6882
Subject:
Stevia rebaudiana, albino, alternative medicine, animal disease models, blood glucose, body weight changes, diabetes, diet, feed intake, functional foods, glycemic effect, glycogen, glycosylation, hemoglobin, insulin, leaves, liver, rats, stevioside, streptozotocin, weight control
Abstract:
BACKGROUND: Stevia (Stevia rebaudiana) natural, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of diabetes. METHODS: The current research was carried out to explore the anti-diabetic effect of aqueous extract of Stevia rebaudiana leaves in albino rats. For this purpose, diabetes was induced by administration of streptozotocin (40 mg/kg body weight, intraperitoneally). The diabetic rats were administered with aqueous stevia extract at different dose levels (200, 300, 400 and 500 ppm/kg b.w) for 8 weeks; the control rats were fed basal diet during this period. RESULTS: Stevia aqueous extract improved caloric management and weight control by decreasing the feed intake and body weight gain. Furthermore, intake of stevia extract resulted in significant (P < 0.05) decrease in the random blood glucose level (− 73.24%) and fasting blood glucose (− 66.09%) and glycosylated (HbA1c) hemoglobin (5.32%) while insulin (17.82 μIU/mL) and liver glycogen (45.02 mg/g) levels significantly improved in the diabetic rats, compared with the diabetic and non-diabetic control rats after 8 weeks study period. CONCLUSIONS: It is concluded that aqueous extact of stevia has anti-diabetic effects in albino rats, and therefore could be promising nutraceutical therapy for the management of diabetes and its associated complications.
Agid:
5967357