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Serum cystatin C concentration measured routinely is a prognostic marker for renal disease in dogs

Iwasa, Naoki, Takashima, Satoshi, Iwasa, Tatsuo, Iwasa, Kazuko, Suzuki, Tomomi, Kobatake, Yui, Kitagawa, Hitoshi, Nishii, Naohito
Research in veterinary science 2018 v.119 pp. 122-126
blood serum, death, dogs, kidney diseases, prognosis, renal function
This study examined the predictive value of serum cystatin C (Cys-C) concentration, measured during routine periodic health examinations, in the renal prognosis of dogs. A cohort of 140 dogs weighing <15 kg whose serum Cys-C concentrations were measured during periodic health examinations from December 2013 to March 2016 were prospectively studied, with renal disease-related death the predicted end point. Of the 140 dogs, nine died from renal diseases during the follow-up period (539 ± 249 days). Serum Cys-C concentrations were higher in the dogs that subsequently died of renal disease than in the censored group (0.8 ± 0.25 vs. 0.3 ± 0.1 mg/dl, respectively; P < .01). Dogs with high serum Cys-C concentrations (>0.55 mg/dl) had a shorter (P < .01) renal disease-specific survival period than those with low serum Cys-C concentrations (≤0.55 mg/dl). In conclusion, high serum Cys-C concentrations in periodic health examinations in dogs <15 kg predicted poorer prognosis for renal function.