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Biomedical applications of genome-scale metabolic network reconstructions of human pathogens
- Dunphy, Laura J, Papin, Jason A
- Current opinion in biotechnology 2018 v.51 pp. 70-79
- animal pathogens, antibiotic resistance, biochemical pathways, evolution, host-pathogen relationships, humans, infectious diseases, therapeutics, virulence
- The growing global threat of antibiotic resistant human pathogens has coincided with improved methods for developing and using genome-scale metabolic network reconstructions. Consequently, there has been an increase in the number of high-quality reconstructions of relevant human and zoonotic pathogens. Novel biomedical applications of pathogen reconstructions focus on three key aspects of pathogen behavior: the evolution of antibiotic resistance, virulence factor production, and host–pathogen interactions. New methods using these reconstructions aim to improve understanding of microbe pathogenicity and guide the development of new therapeutic strategies. This review summarizes the latest ways that genome-scale metabolic network reconstructions have been used to study human pathogens and suggests future applications with the potential to mitigate infectious disease.