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Modeling metabolism of the human gut microbiome
- Magnúsdóttir, Stefanía, Thiele, Ines
- Current opinion in biotechnology 2018 v.51 pp. 90-96
- biochemical pathways, human health, humans, intestinal microorganisms, metabolism, metabolites, microbiome, models
- The human gut microbiome plays an important part in human health. The complexity of the microbiome makes it difficult to determine the detailed metabolic functions and cross-talk occurs between the individual species. In silico systems biology studies of the microbiome can help to identify metabolite exchanges among gut microbes. Constraint-based reconstruction and analysis methods use biochemically accurate genome-scale metabolic networks of microorganisms to simulate metabolism between species in a given microbiome and help generate novel hypotheses on microbial interactions. Here, we review metabolic modeling studies that have investigated metabolic functions of the gut microbiome.