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Roles of histones and nucleosomes in gene transcription

Author:
Huang, Baiqu, Zeng, Qinhua, Bi, Xiaohui, Wang, Yuhong, Li, Yuxin
Source:
Chinese science bulletin 2001 v.46 no.3 pp. 184-188
ISSN:
1001-6538
Subject:
acetyltransferases, gene activation, genes, histones, nucleosomes, transcription (genetics), transcription factors
Abstract:
This article reviews the latest research developments in the field of eukaryotic gene regulation by the structural alterations of chromatin and nucleosomes. The following issues are briefly addressed: (i) nucleosome and histone modifications by both the ATP-dependent remodeling complexes and the histone acetyltransferases and their roles in gene activation; (ii) competitive binding of histones and transcription factors on gene promoters, and transcription repression by nucleosomes; and (iii) influences of linker histone H1 on gene regulation. Meanwhile, the significance and impact of these new research progresses, as well as issues worthwhile for further study are commented.
Agid:
5978382