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Roles of histones and nucleosomes in gene transcription
- Huang, Baiqu, Zeng, Qinhua, Bi, Xiaohui, Wang, Yuhong, Li, Yuxin
- Chinese science bulletin 2001 v.46 no.3 pp. 184-188
- acetyltransferases, gene activation, genes, histones, nucleosomes, transcription (genetics), transcription factors
- This article reviews the latest research developments in the field of eukaryotic gene regulation by the structural alterations of chromatin and nucleosomes. The following issues are briefly addressed: (i) nucleosome and histone modifications by both the ATP-dependent remodeling complexes and the histone acetyltransferases and their roles in gene activation; (ii) competitive binding of histones and transcription factors on gene promoters, and transcription repression by nucleosomes; and (iii) influences of linker histone H1 on gene regulation. Meanwhile, the significance and impact of these new research progresses, as well as issues worthwhile for further study are commented.