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Chemical structure and anti-inflammatory effect of polysaccharide extracted from Morinda citrifolia Linn (Noni)

Author:
Sousa, Stefany Guimarães, Oliveira, Lorena Almeida, de Aguiar Magalhães, Diva, de Brito, Tarcisio Vieira, Batista, Jalles Arruda, Pereira, Cynthia Maria Carvalho, de Souza Costa, Mariana, Mazulo, José Carlos Raposo, de Carvalho Filgueiras, Marcelo, Vasconselos, Daniel Fernando Pereira, da Silva, Durcilene Alves, Barros, Francisco Clark Nogueira, Sombra, Venícios G., Freitas, Ana Lúcia Ponte, de Paula, Regina Célia Monteiro, de Andrade Feitosa, Judith Pessoa, dos Reis Barbosa, André Luiz
Source:
Carbohydrate polymers 2018 v.197 pp. 515-523
ISSN:
0144-8617
Subject:
Morinda citrifolia, anti-inflammatory activity, biological models, cell movement, chemical structure, edema, inflammation, leukocytes, nociception, pain tests, polysaccharides
Abstract:
Polysaccharides extracted from plants are very promising molecules in the field of pharmacotherapy. Knowing this, the aim of this study was to extract, characterize and evaluate the action of the polysaccharide of Morinda citrifolia Linn (Noni-PLS) in biological models of inflammatory processes. The characterization tests shown that sample refers to a heteropolysaccharide composed mainly of homogalacturonan and rhamnogalacturonan. This polysaccharide at dose of 10 mg/kg, when tested in our models of inflammation, showed significant activity in reducing carrageenan-induced paw oedema as well as all mediators edemas. This polysaccharide was able to inhibit the migration of leukocytes to the site of inflammation, and still reduced inflammatory nociception tests. This results, allows us to conclude that the polysaccharide extracted from Morinda citrifolia linn has anti-inflammatory potential since it reversed inflammatory parameters such as edema, leukocyte migration and nociception.
Agid:
5980776