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Omega-3 LCPUFA supplementation improves neonatal and maternal bone turnover: A randomized controlled trial

Kajarabille, Naroa, Peña, Manuela, Díaz-Castro, Javier, Hurtado, Jose A., Peña-Quintana, Luis, Iznaola, Carmen, Rodríguez-Santana, Yessica, Martin-Alvarez, Estefanía, López-Frias, Magdalena, Lara-Villoslada, Federico, Ochoa, Julio J.
Journal of functional foods 2018 v.46 pp. 167-174
biomarkers, bone resorption, corticotropin, cytosol, erythrocytes, fish, insulin, interleukin-6, lactation, leptin, mineral content, mothers, neonates, polyunsaturated fatty acids, pregnancy, pregnant women, randomized clinical trials, tumor necrosis factor-alpha, umbilical arteries, umbilical veins
The aim of this study was to evaluate for the first time the effect of omega-3 LC PUFA supplementation during pregnancy and lactation on bone metabolism in mothers and neonates. 110 pregnant women were divided in two groups: control group (400 mL/day of the control dairy drink); supplemented group (400 mL/day of the fish oil-enriched dairy drink). Plasma bone biomarkers and mineral content in erythrocyte cytosol were assessed. In mothers, DHA supplementation increased OC and OPN levels and decreased IL-6 and TNF-α levels at delivery, increasing PTH levels during lactation. In neonates, DHA supplementation increased ACTH, insulin and leptin, decreasing RANKL and IL-6 in umbilical vein; increased OPG and leptin and diminished TNF-α in umbilical artery; increased OC levels, lowered PTH and TNF-α at birth. DHA supplementation during pregnancy and lactation has beneficial effects on bone turnover in both mother and neonates, representing a non-pharmacological pathway to decrease bone loss.