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Multilayered Scaffold with a Compact Interfacial Layer Enhances Osteochondral Defect Repair

Jia, Shuaijun, Wang, Jing, Zhang, Ting, Pan, Weimin, Li, Zhong, He, Xin, Yang, Chongfei, Wu, Qining, Sun, Wei, Xiong, Zhuo, Hao, Dingjun
ACS applied materials & interfaces 2018 v.10 no.24 pp. 20296-20305
biocompatible materials, biomechanics, biomimetics, cartilage, goats, histology, models, tissue repair
Repairing osteochondral defect (OCD) using advanced biomaterials that structurally, biologically, and mechanically fulfill the criteria for stratified tissue regeneration remains a significant challenge for researchers. Here, a multilayered scaffold (MLS) with hierarchical organization and heterogeneous composition is developed to mimic the stratified structure and complex components of natural osteochondral tissues. Specifically, the intermediate compact interfacial layer within the MLS is designed to resemble the osteochondral interface to realize the closely integrated layered structure. Subsequently, macroscopic observations, histological evaluation, and biomechanical and biochemical assessments are performed to evaluate the ability of the MLS of repairing OCD in a goat model. By 48 weeks postimplantation, superior hyalinelike cartilage and sound subchondral bone are observed in the MLS group. Furthermore, the biomimetic MLS significantly enhances the biomechanical and biochemical properties of the neo-osteochondral tissue. Taken together, these results confirm the potential of this optimized MLS as an advanced strategy for OCD repair.