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Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range
- Cornax, Ingrid, Diel, Diego G., Rue, Cary A., Estevez, Carlos, Yu, Qngzhong, Miller, Patti J., Afonso, Claudio L.
- Journal of general virology 2013 v.94 no.Pt. 6 pp. 1189
- Newcastle disease virus, fibroblasts, macrophages, pathogenicity, sialidase, splenocytes, viral fusion proteins, virus replication
- The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are multifunctional proteins that play critical roles during infection. Here, we assessed the ability of NDV to replicate in macrophages and investigated the contribution of the F and HN proteins to NDV infection/replication in these cells. Results of our study revealed that, while presenting similar replication kinetics in a fibroblast cell line (DF1) or in primary non-adherent splenocytes, the NDV strain CA02 replicates better in macrophages (HD11 and primary adherent splenocytes) than the NDV strain Anhinga/93.