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Nanochannels Photoelectrochemical Biosensor
- Zhang, Nan, Ruan, Yi-Fan, Zhang, Li-Bin, Zhao, Wei-Wei, Xu, Jing-Juan, Chen, Hong-Yuan
- Analytical chemistry 2018 v.90 no.3 pp. 2341-2347
- alkaline phosphatase, aluminum oxide, biosensors, cathodes
- Nanochannels have brought new opportunities for biosensor development. Herein, we present the novel concept of a nanochannels photoelectrochemical (PEC) biosensor based on the integration of a unique CuₓO-nanopyramid-islands (NPIs) photocathode, an anodic aluminum oxide (AAO) membrane, and alkaline phosphatase (ALP) catalytic chemistry. The CuₓO-NPIs photocathode possesses good performance, and further assembly with AAO yields a designed architecture composed of vertically aligned, highly ordered nanoarrays on top of the CuₓO-NPIs film. After biocatalytic precipitation (BCP) was stimulated within the channels, the biosensor was used for the successful detection of ALP activity. This study has not only provided a novel paradigm for an unconventional nanochannels PEC biosensor, which can be used for general bioanalytical purposes, but also indicated that the new concept of nanochannel–semiconductor heterostructures is a step toward innovative biomedical applications.