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Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production

Author:
Bai, Jian, Liu, Dong, Yu, Siwang, Proksch, Peter, Lin, Wenhan
Source:
Tetrahedron letters 2014 v.55 no.45 pp. 6286-6291
ISSN:
0040-4039
Subject:
Bacillus (bacteria), chemical reactions, chemical structure, culture media, lipopolysaccharides, macrophages, mice, nitric oxide, organic compounds, spectral analysis
Abstract:
Chemical examination of the fermentation broth of the marine-derived bacterium Bacillus sp. resulted in the isolation of seven new amicoumacin-type isocoumarin derivatives, namely bacillcoumacins A–G (1–7), together with four known analogues. Their structures were elucidated on the basis of extensive spectroscopic analysis, while the absolute configurations of the new compounds were determined by CD, Mosher’s method, and chemical conversion. Compounds 7 and 9 showed inhibitory effects against the NO production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells.
Agid:
5995475