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C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells
- Douradinha, Bruno, McBurney, Sean P., Soares de Melo, Klecia M., Smith, Amanda P., Krishna, Neel K., Barratt-Boyes, Simon M., Evans, Jared D., Nascimento, Eduardo J.M., Marques, Ernesto T.A.
- Virus research 2014 v.179 pp. 231-234
- Dengue virus, complement, dengue, disease severity, gene expression, immunomodulation, inflammation, messenger RNA, pathogenicity, proteins, screening
- Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.