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Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb

Author:
Yang, Jianbo, Yan, Zheng, Ren, Jin, Dai, Zhong, Ma, Shuangcheng, Wang, Aiguo, Su, Yalun
Source:
Archives of pharmacal research 2018 v.41 no.6 pp. 617-624
ISSN:
0253-6269
Subject:
Reynoutria multiflora, cell lines, cytotoxicity, ethanol, glycosides, high performance liquid chromatography, mass spectrometry, neoplasm cells, nuclear magnetic resonance spectroscopy, roots
Abstract:
Seven new dianthrone glycosides, named polygonumnolides A1–B3 (1–7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1–4 showed moderate cytotoxicity.
Agid:
6001017