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Magnetic carbon nanotube composite for the preconcentration of parabens from water and urine samples using dispersive solid phase extraction

Pastor-Belda, Marta, Marín-Soler, Lidia, Campillo, Natalia, Viñas, Pilar, Hernández-Córdoba, Manuel
Journal of chromatography 2018 v.1564 pp. 102-109
acetylation, adsorption, carbon nanotubes, desorption, detection limit, gas chromatography-mass spectrometry, ionic strength, magnetic materials, magnetism, solid phase extraction, solvents, urine, wastewater treatment
This study describes the use of a magnetic multi-walled carbon nanotube composite for the preconcentration of nine parabens (methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, phenyl and benzylparaben) from water and urine samples after in situ acetylation. The enriched extracts were obtained by dispersive magnetic solid phase extraction (DMSPE) and analysed by gas chromatography with mass spectrometry (GC–MS). Several parameters affecting the adsorption (extraction time, magnetic material mass and ionic strength) and desorption (desorption solvent nature and volume, and desorption time) DMSPE steps were investigated. Matrix-matched calibration was recommended for quantification of the samples. Linearities in the 0.5–150 ng mL−1 range were obtained, depending on the compound. Under the optimal experimental conditions, the limits of detection ranged between 0.03 and 2.0 ng mL-1, depending on the sample matrix and the paraben congener. None of the samples analysed contained the above mentioned parabens. The method was validated with two water samples (harbour and wastewater treatment plant) and two urine samples spiked at two concentration levels. Recoveries in the 81–119% range were obtained.