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Enhanced cytotoxic and apoptotic potential in hepatic carcinoma cells of chitosan nanoparticles loaded with ginsenoside compound K
- Zhang, Jianmei, Wang, Yijun, Jiang, Yunyao, Liu, Tingwu, Luo, Yanyan, Diao, Enjie, Cao, Yufeng, Chen, Liang, Zhang, Liang, Gu, Qian, Zhou, Jinyi, Sun, Fengting, Zheng, Wancai, Liu, Jianxun, Li, Xueqin, Hu, Weicheng
- Carbohydrate polymers 2018 v.198 pp. 537-545
- antineoplastic activity, apoptosis, chitosan, cytotoxicity, dose response, drug carriers, drug therapy, drugs, fluorescence, human cell lines, humans, image analysis, inhibitory concentration 50, liver neoplasms, nanoparticles, neoplasm cells, surfactants, water solubility
- Ginsenoside compound K (CK) has been shown to exhibit anticancer properties. In this study, chitosan nanoparticles loaded with ginsenoside compound K (CK-NPs) were prepared as a delivery system using a self-assembly technique with amphipathic deoxycholic acid-O carboxymethyl chitosan as the carrier, which improved the water solubility of CK. By evaluating drug loading, entrapment efficiency, and in vitro release behavior, the feasibility of CK-NPs as a drug carrier nanoparticle for the treatment of human hepatic carcinoma cells (HepG2) was investigated. Result revealed that CK and CK-NPs showed a dose-dependent inhibitory effect on HepG2 cells with IC50 values of 23.33 and 16.58 μg/mL, respectively. Furthermore, fluorescence imaging demonstrated that CK-NPs promoted cellular uptake in vitro. Therefore, all results indicated that CK-NPs might be a novel drug delivery system to improve the solubility and enhance the cytotoxic and apoptotic potentials of CK for effective liver cancer chemotherapy.