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From the Decomposition of Chemical Warfare Agents to the Decontamination of Cytostatics

Štengl, Václav, Št’astný, Martin, Janoš, Pavel, Mazanec, Karel, Perez-Diaz, José Luis, Štenglová-Netíková, Irena R.
Industrial & engineering chemistry process design and development 2018 v.57 no.6 pp. 2114-2122
decontamination, drug therapy, nitrogen, process design, solvents, sorbents, sulfur
The ability of pilot samples of destructive metal oxide sorbents to decompose a sulfur mustard-type chemical warfare agent into nontoxic products in a nonaqueous solvent was compared with that of the commercial product FAST-ACT. Additionally, samples of the destructive metal oxide sorbents were used to decompose nitrogen mustards, which are used as chemotherapeutic agents, in water, and the results were compared with those of FAST-ACT. All the prepared pilot samples exhibited stoichiometric activities, i.e., the degradation rate expressed by the rate constant, k [s–¹, min–¹], and the decomposition efficiencies, which are expressed by the degree of conversion d [%], higher than those of the comparative commercial product FAST-ACT. Scaling up the sulfur mustard decomposition from the laboratory conditions (reaction volume, 4 L) to quarter-operating (pilot) reaction conditions (reaction volume, 100 L) had a positive effect on the reaction and final product.