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Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems

Author:
Ueki, Akiharu, Un, Keita, Mino, Yuka, Yoshida, Mitsuru, Kawakami, Shigeru, Ando, Hiromune, Ishida, Hideharu, Yamashita, Fumiyoshi, Hashida, Mitsuru, Kiso, Makoto
Source:
Carbohydrate research 2015 v.405 pp. 78-86
ISSN:
0008-6215
Subject:
carbohydrate binding, carbohydrates, drug carriers, in vitro studies, receptors
Abstract:
Novel sugar-conjugated cholesterols, β-Gal-, α-Man-, β-Man-, α-Fuc-, and β-Man-6P-S-β-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showed that the glyco-coated liposomes are efficiently taken up by cells expressing carbohydrate-binding receptors selectively. Glyco-coated liposomes are promising candidates for drug delivery vehicles.
Agid:
6021928