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Carbohydrate conjugation through microwave-assisted functionalization of single-walled carbon nanotubes using perfluorophenyl azides

Author:
Kong, Na, Shimpi, Manishkumar R., Park, Jae Hyeung, Ramström, Olof, Yan, Mingdi
Source:
Carbohydrate research 2015 v.405 pp. 33-38
ISSN:
0008-6215
Subject:
azides, carbohydrates, carbon nanotubes, chemical bonding, lectins, microwave radiation, microwave treatment
Abstract:
Carbohydrate–functionalized single-walled carbon nanotubes (SWNTs) were synthesized using microwave-assisted reaction of perfluorophenyl azide with the nanotubes. The results showed that microwave radiation provides a rapid and effective means to covalently attach carbohydrates to SWNTs, producing carbohydrate–SWNT conjugates for biorecognition. The carbohydrate–functionalized SWNTs were furthermore shown to interact specifically with cognate carbohydrate-specific proteins (lectins), resulting in predicted recognition patterns. The carbohydrate-presenting SWNTs constitute a new platform for sensitive protein- or cell recognition, which pave the way for glycoconjugated carbon nanomaterials in biorecognition applications.
Agid:
6021951