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Genetic polymorphism of complement factor H in cattle

Author:
TABEL, H., GROAT, H. J., KRAAY, G. J., ASTON, W. P.
Source:
Animal genetics 1990 v.21 no.2 pp. 123-128
ISSN:
0268-9146
Subject:
alleles, cattle, complement, electrophoresis, genetic polymorphism, immunoblotting, loci, molecular weight, phenotype
Abstract:
Bovine factor H was found to be polymorphic by the combined techniques of SDS‐polyacrylamide electrophoresis of bovine plasma and immunoblotting. Three phenotypes (S, SF, F) were identified in a sample population of 149 cattle. Variant S and F differed by an apparent molecular weight of 5000 daltons. Family studies demonstrated Mendelian segregation of variants S and F. The data indicate that these genetic variants of bovine factor H are encoded by two codominant alleles at a single autosomal locus.
Agid:
602394