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A bovine class I major histocompatibility complex molecule plus a Theileria parva antigen resembles mouse H‐2Kᵈ

Author:
GODDEERIS, B. M.
Source:
Animal genetics 1990 v.21 no.3 pp. 323-328
ISSN:
1365-2052
Subject:
Theileria parva, antigens, blood, clones, cytotoxicity, haplotypes, major histocompatibility complex, mice, monoclonal antibodies, parasites, steers
Abstract:
Two BoT2⁺, BoT8⁺ cytotoxic T cell clones were generated from peripheral blood of a steer immunized with the intracellular protozoan parasite Theileria parva. Both cytotoxic T cell clones appeared to be restricted by the same major histocompatibility complex (MHC) molecule and were specific for the immunizing parasite clone. However, one of the two clones also recognized uninfected mouse cell lines carrying the H‐2ᵈ haplotype. Inhibition of cytotoxicity with monoclonal antibodies specific for polymorphic determinants on H‐2 molecules confirmed that this CTL clone recognized the H‐2Kᵈ MHC molecule. These results extend to the bovine system observations in other species that foreign MHC mimics self MHC plus antigen.
Agid:
602412