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A frank synthesis of alkyl–aryl ethers from 2-halobenzaldehydes and aromatic olefins without transition metal co-catalyst and ligand

Author:
Kumar, Balagani Sathish, Negi, Arvind S.
Source:
Tetrahedron letters 2015 v.56 no.18 pp. 2340-2344
ISSN:
0040-4039
Subject:
alkenes, carbonates, chemical reactions, chemical structure, ethers, halides, ligands, organic halogen compounds, regioselectivity
Abstract:
An efficient synthesis of alkyl ethers has been developed for o-deactivated aryl halides and 1-halotetralenes. The method shows good regioselectivity towards ortho substituted halides. Alkali metal carbonates (Li2CO3/Na2CO3/K2CO3/Cs2CO3) have been used without a transition metal co-catalyst and ligand. The method is simple, straight-forward and proceeds to afford products in good isolated yields. The method holds potential for future applications in organic synthesis.
Agid:
6025324