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Excretion kinetics of three dominant organochlorine compounds in human milk within the first 6 months postpartum

Song, Shuling, Ma, Xiaodong, Pan, Meng, Tong, Ling, Tian, Qin
Environmental monitoring and assessment 2018 v.190 no.8 pp. 457
HCH (pesticide), World Health Organization, breast feeding, breast milk, excretion, hexachlorobenzene, humans, lactation, milk fat, mothers, persistent organic pollutants, women
Breastfeeding is a specific and important way for women to eliminate harmful substances accumulated in body. Hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and 2,2-bis(p-chlorophenyl)-1,1-dichloroethene (p,p′-DDE) are dominant organochlorine compounds(OCCs) and persistent organic pollutants (POPs) accumulated in human being. Although a 6-month breastfeeding was suggested by the World Health Organization (WHO), the excretion characteristics of OCCs in human milk during the first 6-month lactation remain controversial. The main purpose of this study was to continuously monitor the three dominant OCC concentrations and reveal their elimination characteristic in human milk within the first 6-month lactation. To do that, with one sample per month, during their first 6-month lactation, human milk samples were continuously collected from 40 mothers after their first birth. The result showed that the concentrations of the three OCCs in human milk during the lactation continuously decreased from 51.7 to 39.9 μg/kg milk lipids for HCB, from 136.5 to 84.8 μg/kg milk lipids for β-HCH, and from 307.3 to 192 μg/kg milk lipids, respectively. The excretion kinetics of each compound in milk lipids fitted zero-order kinetics during the 6-month lactation. The excretion rate of the three OCCs was approximately 3% per month for HCB and 7% per month for the other two compounds during the lactation, with tdₑc ₁/₂ of 13 months for HCB, 7.5 months for β-HCH, and 8 months for p,p′-DDE. The excretion rate of the target compounds depended on initial deposited levels, compound properties, and exposure or input source.