PubAg

Main content area

Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand

Author:
Wang, Hao, Bai, Zibo, Jiao, Tangqian, Deng, Zhiqiang, Tong, Huarong, He, Gang, Peng, Qian, Chen, Gong
Source:
Journal of the American Chemical Society 2018 v.140 no.10 pp. 3542-3546
ISSN:
1520-5126
Subject:
Lewis bases, alkenes, catalytic activity, enantioselectivity, indoles, ligands, palladium
Abstract:
A Pd-catalyzed amide-directed enantioselective hydrocarbofunctionalization of unactivated alkenes with C–H nucleophiles has been developed using a chiral monodentate oxazoline (MOXin) ligand. Various indoles react at C3 position with aminoquinoline-coupled 3-alkenamides to give γ addition products in good to excellent yield and enantioselectivity. This study represents an important advance of the development of chiral monodentate oxazoline ligands, which have been underexplored for asymmetric catalysis.
Agid:
6033130