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Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand
- Wang, Hao, Bai, Zibo, Jiao, Tangqian, Deng, Zhiqiang, Tong, Huarong, He, Gang, Peng, Qian, Chen, Gong
- Journal of the American Chemical Society 2018 v.140 no.10 pp. 3542-3546
- Lewis bases, alkenes, catalytic activity, enantioselectivity, indoles, ligands, palladium
- A Pd-catalyzed amide-directed enantioselective hydrocarbofunctionalization of unactivated alkenes with C–H nucleophiles has been developed using a chiral monodentate oxazoline (MOXin) ligand. Various indoles react at C3 position with aminoquinoline-coupled 3-alkenamides to give γ addition products in good to excellent yield and enantioselectivity. This study represents an important advance of the development of chiral monodentate oxazoline ligands, which have been underexplored for asymmetric catalysis.