PubAg

Main content area

Development and utilization of a bovine type I collagen microfibril model

Author:
Brown, Eleanor M.
Source:
International journal of biological macromolecules 2013 v.53 pp. 20
ISSN:
0141-8130
Subject:
cattle, collagen, engineering, models, prediction, protein structure, tissue scaffolds
Abstract:
The structure of fibrous collagen, a long triple helix that self-associates in a staggered array to form a matrix of fibrils, fibers and fiber bundles, makes it uniquely suitable as a scaffold for biomaterial engineering. A major challenge for this application is to stabilize collagen structure by means that are acceptable for the end use. The bovine type I collagen microfibril model, built by computer assisted modeling, comprised of five right-handed triple helices in a left-handed super coil containing gap and overlap regions as well as the nonhelical telopeptides is a tool for predicting or visualizing chemistry to stabilize the matrix, insert an active agent, or otherwise modify collagen.
Agid:
60351
Handle:
10113/60351