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Mx GTPases: dynamin-like antiviral machines of innate immunity

Author:
Haller, Otto, Staeheli, Peter, Schwemmle, Martin, Kochs, Georg
Source:
Trends in microbiology 2015 v.23 no.3 pp. 154-163
ISSN:
0966-842X
Subject:
Human immunodeficiency virus 1, Influenza A virus, guanosinetriphosphatase, human population, humans, innate immunity, interferons, proteins, virus replication, viruses
Abstract:
The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.
Agid:
6041009